昭和医科大学病態分子生化学研究センター

沿革

病態分子生化学研究センターは、昭和医科中国竞彩网を活かした学部横断の研究拠点として、2024年5月に開設されました。開設当初は医学部生化学講座および歯学部口腔生化学講座の二講座で構成されていましたが、2026年4月からは薬学部基礎薬学講座生物化学部門が加わり、現在では三講座が協同して生化学を基礎とする研究を推進しています。

病態分子生化学研究センターのビジョン?ミッション

病態分子生化学研究センターでは、生化学を基礎とした最新の研究手法を取り入れ、様々な病態のメカニズムを分子レベルで明らかにすることを目標とします。
そして、分子メカニズムに基づいた治療法の開発、幅広い視点を持つ優れた若手研究者の育成を目指し、世界の第一線で研究を遂行します。

論文発表

2026年度

Toyoda F, Haraguchi S, Yamamoto K, Matsunaga M, Takase M, Nakada T, Nakamura M, Hasunuma I, Tsutsui K, Kikuyama S.
The abdominal gland of the male red-bellied newt generates steroids that act synergistically with sodefrin as a courtship pheromone. 

Physiol Behav. 2026 Aug 1;312:115347. doi: 10.1016/j.physbeh.2026.115347.

Otani J, Nishio M, Tokita R, Hikasa H, Nishimori M, Dan S, Naguro I, Ichijo H, Miyanishi M, Sasaki T, Nishina H, Mak TW, Maehama T, Suzuki A. 

SAMD4 represses VGLL4 mRNA to activate TEAD and promote cancer progression.
Oncogene. 2026 Jun;45(22):2171-2182. doi: 10.1038/s41388-026-03778-w.

Makiyama T, Aiuchi T, Mikajiri T, Obama T, Chatani M, Azetsu Y, Yamada A, Sasa K, Itabe H. 

NEK2A regulates PLIN2 expression through a SERBP1 dependent pathway. 

iScience. 2026 Jun 9;29(6):116254. doi: 10.1016/j.isci.2026.116254.

Uchiyama J, Shimizu Y, Unoki T, Kasamatsu S, Ida T, Ihara H, Kim YG, Hase K, Miura Y, Maehama T, Kusano M, Umezawa K, Akiyama M. 

Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides. 

Redox Biol. 2026 May;92:104123. doi: 10.1016/j.redox.2026.104123.

Liu A, Ishiguro M, Matsumura Y, Kwak K, Shimizu S, Watabe K, Nagashima H, Maekawa S, Iwata T. 

Consuming heat-inactivated Lactiplantibacillus pentosus ONRICb0240-containing postbiotics reduces gingival inflammation: A double-blind randomized clinical trial. 

J Periodontol. 2026 Apr 19. doi: 10.1002/jper.70141.

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2025年度

Xue F, Sheng R, Wang Q, Wang Y, Lei K, Liu Y, Yu L, Tsukasaki M, Ding C, Li J, Yuan Q, Cao S. 

Engineered self-assembly of plant proteins into α-ketoglutarate-loaded nanoplatforms for osteoarthritis treatment. 

J Control Release. 2025 Dec 10;388(Pt 1):114326. doi: 10.1016/j.jconrel.2025.114326.

Negishi S, Shibusaka K, Maemura M, Tsukasaki M, Ohba S,Tanaka S, Saito T, Suzuki Y, Okada H, Yano F. 

Regen Ther. 2025 Dec 4;31:101051. doi: 10.1016/j.reth.2025.101051.

Otsuka M, Takeuchi Y, Moriyama M, Egoshi S, Goto Y, Gu T, Kimura AP, Haraguchi S, Yoshii T, Takeuchi S, Matsuyama M, Bentley GE, Aizawa S. 

Neuromedin U deficiency disrupts daily testosterone fluctuation and reduces wheel-running activity in rats. 

Endocrinology. 2025 Jun 10;166(8):bqaf102. doi: 10.1210/endocr/bqaf102. 

Higurashi M, Mori K, Nakagawa H, Uchida M, Ishikawa F, Shibanuma M. 

Respiratory complex I-mediated NAD⁺ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7. 

Mol Oncol. 2025 Jun;19(6):1775-1796. doi: 10.1002/1878-0261.13808.

Nishio M, Yamaguchi K, Otani J, Yuguchi K, Kohno D, Sasaki T, Kitamura T, Shinohara M, Soga T, Kawamura K, Sasaki AT, Oshima M, Hikasa H, Woo M, Sasaki T, Nishina H, Nakao K, Maehama T, Suzuki A. 

MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes. 

Proc Natl Acad Sci U S A. 2025 Apr 29;122(17):e2424741122. doi: 10.1073/pnas.2424741122. 

Maemura M, Morita M, Ogata S, Miyamoto Y, Ida T, Shibusaka K, Negishi S, Hosonuma M, Saito T, Yoshitake J, Takata T, Matsunaga T, Mishima E, Barayeu U, Akaike T, Yano F. 

Supersulfides contribute to joint homeostasis and bone regeneration. 

Redox Biol. 2025 Apr;81:103545. doi: 10.1016/j.redox.2025.103545.

Shibusaka K, Negishi S, Sakai N, Kim Y, Okada H, Yano F.

Synergistic effects of estrogen deficiency and articular disk derangement on condylar bone loss.

J Oral Biosci. 2025 Mar;67(1):100616. doi: 10.1016/j.job.2025.100616.

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2024年度

Watanabe Y, Obama T, Makiyama T, Itabe H. 

Oxysterols Suppress Release of DNA from Granulocytes into Extracellular Space After Stimulation with Phorbol Myristate Acetate. 

Biomedicines. 2024 Nov 6;12(11):2535. doi: 10.3390/biomedicines12112535.

Nakamura K, Tsukasaki M, Tsunematsu T, Yan M, Ando Y, Huynh NC, Hashimoto K, Gou Q, Muro R, Itabashi A, Iguchi T, Okamoto K, Nakamura T, Nakano K, Okamura T, Ueno T, Ito K, Ishimaru N, Hoshi K, Takayanagi H. 

The periosteum provides a stromal defence against cancer invasion into the bone. 

Nature. 2024 Oct;634(8033):474-481.

 

Toba K, Yamada A, Sasa K, Shirota T, Kamijo R.

Expression of Kielin/chordin-like protein is regulated by BMP-2 in osteoblasts. 

Bone Rep. 2024 Jul 20;22:101793. doi: 10.1016/j.bonr.2024.101793. 

 

Ohinata H, Phimarn W, Mizuno M, Obama T, Fukuhara K, Makiyama T, Watanabe Y, Itabe H. 

Suppressive effect of resveratrol, catechin and their conformationally constrained analogs on neutrophil extracellular trap formation by HL-60-derived neutrophils. 

J Clin Biochem Nutr. 2024 Jul;75(1):17-23. doi: 10.3164/jcbn.23-80.

 

Inoue T, Yamamoto Y, Sato K, Okemoto-Nakamura Y, Shimizu Y, Ogawa M, Onodera T, Takahashi Y, Wakita T, Kaneko MK, Fukasawa M, Kato Y, Noguchi K.

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies.

iScience. 2024 Feb 29;27(4):109363. doi: 10.1016/j.isci.2024.109363.